Based on an analysis of factors that determine the effectiveness of herbicides, a hypothesis was proposed, that the join use of an enzyme inhibitor and an inhibitor of the synthesis of this enzyme’s coenzyme should result in a synergistic interaction. To test this hypothesis, a field experiment was conducted in winter wheat crops to study the interaction effect when using a mixture of the herbicide diflufenican, an inhibitor of phytoene desaturase, and herbicide tolpyralate, an inhibitor of hydroxyphenylpyruvate dioxygenase, as the latter is involved in the synthesis of plastoquinone, which is a coenzyme for phytoene desaturase. It was found, that interaction between tolpyralate and diflufenican was additive with respect to broadleaf species, and synergistic with respect to grass species. It was concluded, that although the join use of an enzyme inhibitor and an inhibitor of the synthesis of this enzyme’s coenzyme does not absolutely guarantee a synergistic interaction, the absence of antagonism and presence of additive or synergistic interactions for plant species with contrasting levels of resistance to the individual components indicates the potential for creating anti-resistance herbicide compositions using this algorithm.
Keywords: herbicides, resistance, interaction
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