Fiziol. rast. genet. 2023, vol. 55, no. 5, 371-394, doi:

What is missing to create new herbicides and solving the problem of resistance?

Morderer Ye.

  • Institute of Plant Physiology and Genetics, National Academy of Sciences of Ukraine 31/17 Vasylkivska St., Kyiv, 03022, Ukraine

The issue of weeds resistance to herbicides and potential solutions of this problem are considered. Alternatives to chemical methods of weed control are discussed. It is concluded that the introduction of alternative methods of weed control will reduce the relative part of herbicides in crop protection technologies, but complete rejection of the use of herbicides is unlikely. At the same time, the problem of resistance requires significant improvement of the chemical method, primarily by reducing the directed selection pressure of herbicides. It is stated that the most effective way to managing resistance is the complex application of herbicides with different mode of action. The requirements for anti-resistant herbicide compositions are discussed. It is noted that the current range of herbicides limits the choice of components for creating such compositions. It is concluded that the development of new effective herbicides with mode of action distinct from existing ones is necessary to managing resistance. Methods for finding new sites of herbicide action and causes for the unsatisfactory effectiveness of their implementation are discussed. The opinion is substantiated that to determine the criteria for choosing new sites of herbicide action, it is necessary to elucidate the mechanisms of herbicide-induced pathogenesis, and data on the involvement of programmed cell death in this process are discussed. Another important direction of research, necessary for determining these criteria, is the study of feedback loops that regulate the functioning of metabolic pathways and physiological systems of plants. The data on the peculiarities of the functioning of feedback loops, which control the expression of genes encoding the sites of action of the most effective classes of herbicides, are discussed.

Keywords: herbicides, resistance, new sites of action, herbicide-induced pathogenesis, programmed cell death, feedback regulation

Fiziol. rast. genet.
2023, vol. 55, no. 5, 371-394

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