Fiziol. rast. genet. 2021, vol. 53, no. 3, 262-276, doi: https://doi.org/10.15407/frg2021.03.262

Investigations of mechanisms of action of physiologically active substances and herbicides: main achievements and innovative developments

Morderer Ye.Yu., Guralchuk Zh.Z.

  • Institute of Plant¬† Physiology and Genetics, National Academy of Sciences of Ukraine¬† 31/17 Vasylkivska St., Kyiv, 03022, Ukraine

The problems and main achievements of researches of mechanisms of action of physiologically active substances, including herbicides are analyzed. Considerable attention is paid to the results of fundamental researches aimed at studying the theoretical bases of plant growth and development management, and applied developments to create growth regulators of natural origin, and the use of synthetic and natural physiologically active substances in agriculture. The main achievements of researches on the physiology of herbicides action: elucidation of specific sites of herbicide action, determination of mechanisms of uptake, translocation and detoxification of active substances of herbicides in plants, establishment of basic patterns of interaction effects in herbicide complexes are described. Innovative developments are discussed: environmentally friendly weed control technologies, creation of herbicide compositions to prevent the emergence of resistance. It is concluded that the discovery of the mechanisms of herbicide-induced pathogenesis will open opportunities for the search for new highly effective herbicides, solving the problem of resistance and further improving the chemical method of weed control.

Keywords: physiologically active substances, herbicides, weeds, resistance, induced pathogenesis, complex application of herbicides

Fiziol. rast. genet.
2021, vol. 53, no. 3, 262-276

Full text and supplemented materials

Free full text: PDF  

References

1. Kalinin, F.L. (1959). Embryonic development of plants. Kyiv: Urozhay [in Russian].

2. Kalinin, F.L., Sarnatskaya, V.V. & Polishchuk, V.E. (1980). Tissue culture methods in plant physiology and biochemistry. Kyiv: Naukova dumka [in Russian].

3. Kalinin, F.L., Kushnir, G.P. & Sarnatskaya, V.V. (1992). Microclonal plant propagation technology. Kyiv: Naukova dumka [in Russian].

4. Musiyaka, V.K. (1984). Embryonic culture as a way to obtain distantly related hybrids. Kyiv. Dep. VINITI 05/25/84, No. 3452-3484 [in Russian].

5. Sarnatskaya, V.V. (1983). The cell cycle and the proliferative activity of plant tumors. In: Cell cycle of plants (pp. 175-183), Kyiv: Naukova dumka [in Russian].

6. Sarnatskaya, V.V. (1993). Physiological aspects of tumor growth in plants. Kyiv: Naukova dumka [in Russian].

7. Grodzinsky, D.M. & Gudkov, I.N. (1973). Protection of plants from radiation damage. Moscow: Atomizdat [in Russian].

8. Gudkov, I.N. & Grodzinsky, D.M. (1976). The role of asynchrony of cell division and heterogeneity of the meristem in the radio resistance of plants. In: Mechanisms of radioresistance of plants (pp. 110-137), Kyiv: Naukova dumka [in Russian].

9. Troyan, V.M. (1998). Cell cycle of plants and its regulation. Kyiv: Naukova dumka [in Ukrainian].

10. Kalinin, F.L. & Merezhinsky, Yu.G. (1965). Plant growth regulators. Kyiv: Naukova dumka [in Russian].

11. Kalinin, F.L. (1978). Fundamentals of molecular biology. Kyiv: Vyshcha shkola [in Russian].

12. Kalinin, F.L. (1984). Biologically active substances in crop production: theory and practice. Kyiv: Naukova dumka [in Russian].

13. Kalinin, F.L. (1986).Theoretical foundations of plant growth, development and productivity management by endogenous and exogenous factors. Fiziologia i biokhimia kult. rastenij, 18, No. 6, pp. 537-555 [in Russian].

14. Melnichuk, Yu.P. (1990). Effect of cadmium ions on cell division and plant growth. Kyiv: Naukova dumka [in Russian].

15. Kurchii, B.A. (1993). Functionally active groups of bioregulators. Fiziologia i biokhimia kult. rastenij, 25, No. 1, pp. 82-92 [in Russian].

16. Kurchii, B.A. (1998). What growth regulators regulate. Kyiv: Logos [in Russian].

17. Yavorskaya, V.V., Dragovoz, I.V., Savinsky, S.V., Markova, V.E. & Kofman, I.Sh. (1989). Determination of cyclic 3',5'-AMP (cAMP) in plant tissues by high-performance liquid chromatography. Fiziologia i biokhimia kult. rastenij, 20, No. 6, pp. 607-614 [in Russian].

18. Dragovoz, I.V., Yavorskaya, V.K. & Naumenko, E.G. (1994). Influence of cAMP on the activity of RNA polymerase II of isolated nuclei of rye seedlings under the influence of low positive temperatures. Dopovidi Natsional'noyi akademiyi nauk Ukrainy, No. 3, pp. 148-151 [in Russian].

19. Dragovoz, I.V., Yavorskaya, V.K. & Melnichuk, Yu.P. (1997). Identification of cAMP phosphodiesterase, sensitive to Ca2+ ions and calmodulin, and its possible role in the interaction of the adenylate cyclase system with phytohormones. Biopolimery i kletka, 13, No. 2, pp. 116-120 [in Russian]. https://doi.org/10.7124/bc.000472

20. Yavorskaya, V.K. & Dragovoz, I.V. (1999). Physiological role of 3',5'-adenosine monophosphate in a plant cell. Kyiv: Naukova dumka [in Russian].

21. Savinsky, S.V., Kofman, I.Sh., Kofanov, V.I. & Stasevskaya, I.P. (1987). Methodological approaches to the determination of phytohormones using spectrodensi­tometric thin-layer chromatography. Fiziologia i biokhimia kult. rastenij, 19, No. 2, pp. 210-215 [in Russian].

22. Savinsky, S.V., Dragovoz, I.V. & Pedchenko, V.K. (1991). Determination of content of zeatin, indolyl-3-acetic and abscisic acids in plant sample by high performance liquid chromatography. Fiziologia i biokhimia kult. rastenij, 23, No. 6, pp. 611-619 [in Russian].

23. Savinsky, S.V., Yavorskaya, V.K. & Dragovoz, I.V. (1995). New environmentally friendly cytokinin preparations. Dopovidi Natsional'noyi akademiyi nauk Ukrainy, No. 5, pp. 117-120 [in Russian].

24. Dragovoz, I.V. (1998). Wastes of alcohol yeast production as a source of phytohormones. Dopovidi Natsional'noyi akademiyi nauk Ukrainy, No. 3, pp. 170-174 [in Ukrainian].

25. Dragovoz, I.V., Volkogon, M.V., Yavorska, V.K., Musienko, M.M. & Bogdanovich, A.V. (2006). Physiological activity of components of vermicompost and creation of a complex growth regulator on their basis. Fiziologia i biokhimia kult. rastenij, 38, No. 4, pp. 292-300 [in Ukrainian].

26. Antonyuk, V.P., Dragovoz, I.V., Makoveichuk, T.I., Bogdanovich, A.V. & Yavorska, V.K. (2009). Technology of plant growth regulator obtaining from waste products of food industry. Nauka ta innovatsii, 5, No. 3, pp. 25-39 [in Ukrainian]. https://doi.org/10.15407/scin5.03.025

27. Lobov, V.P. & Kalinin, F.L. (1965). Results and prospects of the chemical method of combating Russian knapweed. In: Russian knapweed and measures to combat it (pp. 86-102), Kyiv: UASHN [in Ukrainian].

28. Kalinin, F.L. (1989). Application of growth regulators in agriculture. Kyiv: Urozhay [in Ukrainian].

29. Kalinin, F.L. & Boreyko, V.K. (1981). Theoretical bases of application of hydrazide of maleic acid in crop production. Fiziologia i biokhimia kult. rastenij, 13, No. 1, pp. 3-13 [in Russian].

30. Gvozdyak, I.N., Kalinin, F.L., Kochina, O.A. & Boreyko, V.K. (1980). MH-sodium against infestation by broomrape in tobacco crops. Zashchyta rastenij, No. 6, p. 56 [in Russian].

31. Kalinin, F.L. & Kurchii, B.O. (1982). Influence of retardants on stability of winter rye against lodging and formation of its harvest. Visnyk s.-h. nauky, No. 9, pp. 22-26 [in Ukrainian].

32. Kalinin, F.L. & Kurchii, B.A. (1987). The ethephon effect on formation of cell wall structure in winter rye stem. Fiziologia i biokhimia kult. rastenij, 19, No. 1, pp. 72-76 [in Russian].

33. Kalinin, F.L. & Chaiko, A.L. (1986). Possible ways to decrease sugar losses when storing sugar beet. Fiziologia i biokhimia kult. rastenij, 18, No. 5, pp. 419-426 [in Russian].

34. Merezhinsky, Yu.G. (1968). Uptake and inactivation of herbicides in plants. In Physiology and biochemistry of plants in Ukraine (pp. 110-122), Kyiv: Naukova dumka [in Russian].

35. Merezhinsky, Yu.G., Vasilchenko, V.F. & Kofman, I.Sh., Dubrovskaya A.A. & Akimenko, L.I. (1984). Treflan metabolism in the soil and the uptake of its metabolites by plants. In Mechanism of action of herbicides and synthetic plant growth regulators (pp. 110-122), Ufa [in Russian].

36. Lapina, T.V., Khodeeva, L.V. & Merezhinsky, Yu.G. (1980). Effect of herbicides on the functions of chloroplast. Fiziologia i biokhimia kult. rastenij, 12, No. 5, pp. 535-539 [in Russian].

37. Merezhinsky, Yu.G. & Sharmankin, S.V. (1986). Assembly of microtubules in vitro in the presence of trifluralin. Fiziologia i biokhimia kult. rastenij, 18, No. 3, pp. 299-303 [in Russian].

38. Lapina, T.V., Khodeeva, L.V. & Merezhinsky, Yu.G. (1981). About the mechanism of action of the promethrin on the plant. Fiziologia i biokhimia kult. rastenij, 13, No. 3, pp. 301-305 [in Russian].

39. Lapina, T.V. & Khodeeva, L.V. (1982). The behavior of sim-triazine in chloroplasts. Fiziologia i biokhimia kult. rastenij, 14, No. 3, pp. 232-236 [in Russian].

40. Morderer, Ye.Yu. (2000). Selective phytotoxicity of herbicides. Kyiv: Logos [in Russian].

41. Schwartau, V.V. & Mykhalska, L.M. (2013). Herbicides. Physico-chemical and biological properties (Vol. 2). Kyiv: Logos [in Ukrainian].

42. Grigorenko, N.V., Vasilchenko, V.F., Merezhinsky, Yu.G., Morgun, V.V., Logvinenko, V.F. & Sharmankin, S.V. (1986). Cytogenetic activity of herbicide treflane and its metabolites wich affect the maize seeds. Cytolohiya i henetyka, 20, pp. 294-298 [in Russian].

43. Kofman, I.Sh. (1980). Gas chromatographic determination of simazine, atrazine and promethrin at co-presence in cultivated plants. Fiziologia i biokhimia kult. rastenij, 12, No. 2, pp. 198-201 [in Russian].

44. Kofman, I.Sh. & Nizhko, L.V. (1984). Determination of microquantities of herbicides of a group of acylanilides by thin layer chromatography. Fiziologia i biokhimia kult. rastenij, 16, No. 3, pp. 290-292 [in Russian].

45. Schwartau, V.V. & Trach, V.V. (2000). Detection of the content of herbicides in environmental objects by determining the activity of acetolactate synthase. Questions of bioindication and ecology, 5, No. 3, pp. 104-107 [in Ukrainian].

46. Morderer, Ye.Yu. (1985). Weed control with the help of high-voltage electrical discharge and microwave radiation. In Regulatory mechanisms of physiological processes in plants (pp. 110-122), Kyiv: Naukova dumka [in Russian].

47. Morderer, Ye.Yu. & Grodzinsky, D.M. (1988). Peroxidation of lipids and regulation of the state of organic dormancy of seeds. Ukr. Bot. J., 45, No. 6, pp. 84-90 [in Ukrainian].

48. Morderer, Ye.Yu., Grodzinsky, D.M. & Khotyaintsev, V.M. (1992). The model of lipid peroxidation reactions as related to the organic dormancy state of seeds. Ukr. Bot. J., 49, No. 5, pp. 103-106 [in Ukrainian].

49. Morderer, Ye.Yu. (2008). Current state, problems and prospects of the development of chemical method of weed control. Fiziologia i biokhimia kult. rastenij, 40, No. 6, pp. 492-502 [in Ukrainian].

50. Merezhinsky, Yu.G. & Veselovsky, I.V. (1983). Herbicide guide. Kyiv: Urozhay [in Ukrainian].

51. Ivashchenko, O.O. & Merezhinsky, Yu.G. (2001). Methods of testing agrochemicals. In: Tribel, S.O. (Ed.). Herbicides and desiccants. Methods of testing and application of pesticides (pp. 372-387), Kyiv: Svit [in Ukrainian].

52. Schwartau, V.V. (2004). Regulation of activity of herbicides with the help of chemical compounds. Kyiv: Lohos [in Ukrainian].

53. Guralchuk, Zh.Z., Sychuk, A.M., Gumenyuk, O.V., Rodzevich, O.P., Grinyuk, S.O. & Morderer, Ye.Yu. (2017). Efficacy of weed control by different formulations of glyphosate herbicide depending on water quality and application of companion gold adjuvant. Fiziol. rast. genet, 49, No. 6, pp. 507-514 [in Ukrainian]. https://doi.org/10.15407/frg2017.06.513

54. Sorokina, S.I., Rodzevich, O.P., Guralchuk, Zh.Z. & Morderer, Ye.Yu. (2016). Joint application of Harmony and Pulsar herbicides with Trend 90 adjuvant in soybean crops. Karantin i zahist roslun, No. 5, pp. 1-3 [in Ukrainian].

55. Morderer, Ye.Yu., Guralchuk, Zh.Z., Rodzevych, O.P. & Novak, L. (2020). The efficiency of adjuvant AGNS 1056-X joint application with herbicides aryloxyphenoxy propionic acid derivatives. Fiziol. rast. genet., 52, No. 3, pp. 224-237. https://doi.org/10.15407/frg2020.03.224

56. Sosnovaya, O.N. (1983). Herbicides and mineral nutrition of plants. Kyiv: Naukova dumka [in Russian].

57. Merezhinsky, Yu.G., Lukyanchenko, A.S., Semenov, A.G. & Ivanishchev, V.N. (1991). Application of new herbicides and their complexes in the cultivation of tomatoes. Fiziologia i biokhimia kult. rastenij, 23, No. 2, pp. 192-196 [in Russian].

58. Merezhinsky, Yu.G., Semenov, A.G. & Dudinets, S.M. (1983). Complex application of herbicides on corn crops. Khimiya v sel'skom khozyaystve, No. 7, pp. 37-38 [in Russian].

59. Merezhinsky, Yu.G., Semenov, A.G. & Lukyanchenko, A.S. (1986). Herbicidal complexes on carrots. Khimiya v sel'skom khozyaystve, No. 3, pp. 62-63 [in Russian].

60. Merezhinsky, Yu.G., Semenov, A.G. & Samokhval, E.K. (1989). Application of acetal, dual, devrinol and their complexes during potato cultivation. Fiziologia i biokhimia kult. rastenij, 21, No. 6, pp. 598-602 [in Russian].

61. Semenov, A.G. & Merezhinsky, Yu.G. (1985). The complex application of herbicides is an effective way to control weeds when cultivating corn. Fiziologia i biokhimia kult. rastenij, 17, No. 4, pp. 373-376 [in Russian].

62. Semenov, A.G., Merezhinsky, Yu.G. & Dudinets, S.M. (1983). Complex application of herbicides is an effective way to control weeds in sugar beet crops. Fiziologia i biokhimia kult. rastenij, 15, No. 3, pp. 280-283 [in Russian].

63. Morderer, Ye.Yu., Guralchuk, Zh.Z. & Morgun, V.V. (2018). The problem of controlling segetal vegetation in agrophytocenoses in the context of biodiversity conservation. Ukr. Bot. J., 75, No. 6, pp. 552-563 [in Ukrainian]. https://doi.org/10.15407/ukrbotj75.06.552

64. Kalinin, F.L., Merezhinsky, Yu.G. & Volovik, O.I. (1968). Biochemistry of synergistic action of derivatives of symmetric atrazine and 2,4-D. Physiological and biochemical bases of plant nutrition. Kyiv: Naukova dumka, No. 4, pp. 20-27 [in Russian].

65. Merezhinsky, Yu.G. & Volovik, O.I. (1966). Biochemistry of synergistic action of derivatives of symmetric atrazine and 2,4-D. In Physiology and biochemistry of plant growth regulation. Kyiv: Naukova dumka [in Russian].

66. Merezhinsky, Yu.G. & Lapina, T.V. (1974). Destruction of exergonic processes in plants with the joint action of simazine and 2,4-D. Fiziologia i biokhimia kult. rastenij, 6, No. 6, pp. 596-600 [in Russian].

67. Morderer, Ye.Yu. & Merezhinsky, Yu.G. (2009). Herbicides. Mechanisms of action and practice of application. Kyiv: Logos [in Ukrainian].

68. Morderer, Ye.Yu., Nizkov, Ye.I., Radchenko, M.P., Rodzevich, O.P. & Sychuk, A.M. (2014). Control of weeds in crops with the help of herbicides. Kyiv: Logos [in Ukrainian].

69. Morderer, Ye.Yu. & Merezhinsky, Yu.G. (2001). Tank mixtures of herbicides. Application of preparations of derivatives of sulfonylureas with derivatives of aryloxyfenoxypropionic acid for protection of winter wheat and spring barley crops. Zakhyst roslyn, No. 9, pp. 11-12 [in Ukrainian].

70. Morderer, Ye.Yu., Merezhinsky, Yu.G. & Lukyanchenko, O.S. (2002). Application of tank mixtures of granstar and lancetum herbicides on winter wheat crops. Fiziologia i biokhimia kult. rastenij, 34, No. 1, pp. 35-39 [in Ukrainian].

71. Morderer, Ye.Yu. & Lukyanchenko, O.S. (2002). Application of tank mixtures of herbicide titus with auxinic herbicides on corn crops. Fiziologia i biokhimia kult. rastenij, 34, No. 3, pp. 265-269 [in Ukrainian].

72. Guralchuk, Zh.Z., Sorokina, S.I., Rodzevich, O.P. & Morderer, Ye.Yu. (2012). Soybean nitrogen-fixing activity at combined application of herbicides with microfertilizers. Uch. zapysky Tavrich. nats. un-tu im. V.I. Vernads'koho. Ser. Biolohiya, khimiya, 25 (64), No. 4. pp. 34-39 [in Ukrainian].

73. Sorokina, S.I., Rodzevich, O.P. & Morderer, Ye.Yu. (2012). Effectiveness of weeds control and selectivity for soybean plants at complex application of herbicides imazamox and tyfensulfuronmethyl. Fiziologia i biokhimia kult. rastenij, 44, No. 4, pp. 336-346 [in Ukrainian].

74. Morderer, Ye.Yu., Radchenko, M.P., Kyforuk, I.M. & Pavlenko, V.V. (2020). Selectivity and efficacy of herbicide GF-3488 containing synthetic auxins halauxifen-methyl and clopyralid in winter oilseed rape crops in Ukraine. Fiziol. rast. genet., 2, No. 5, pp. 388-400. https://doi.org/10.15407/frg2020.05.388

75. Morderer, Ye.Yu., Merezhinsky, Yu.G., Grigorenko, N.V. & Lukyanchenko, A.S. (1999). Application of herbicides with the addition of insectofungicides in the cultivation of potatoes. Visn. ahrar. nauky, No. 9, pp. 22-25 [in Russian].

76. Morderer, Ye.Yu., Merezhinsky, Yu.G., Grigorenko, N.V. & Lukyanchenko, O.S. (1998). Tank mixtures of pesticides allow us to significantly improve the protection of sowing tomatoes from weeds and diseases. Zakhyst roslyn, No. 9, pp. 16-17 [in Ukrainian].

77. Morderer, Ye.Yu., Merezhinsky, Yu.G., Grigorenko, N.V. & Lukyanchenko, O.S. (2002). Effective mixture. Application of Hesagard and Super Fusilade herbicides with the addition of insecticide Decis on carrots sowings. Zakhyst roslyn, No. 2, pp. 17-18 [in Ukrainian].

78. Pat. 131799 UA, IPC A01N 37/10, A01N 47/28, Selective tank mix of herbicides for control of annual dicotyledonous weeds in sunflower crops and prevention of herbicide resistance, Morderer, Ye.Yu., Sychuk, A.M., Rodzevich, O.P., Grinyuk, S.O., Publ. 25.01.2019 [in Ukrainian].

79. Pat. 131800 UA, IPC A01N 37/10, A01N 47/28, Synergistic tank mixture of herbicides for control of annual dicotyledonous and cereal weeds in sunflower crops and prevention of herbicide resistance, Morderer, Ye.Yu., Sychuk, A.M., Rodzevich, O.P., Grinyuk, S.O., Publ. 25.01.2019 [in Ukrainian].

80. Kraehmer, H., Laber, B., Rosinger, C. & Shulz, A. (2014). Herbicides as weed control agents: state of the art: I. Weed control research and safener technology: the path to modern agriculture. Plant Physiology, 166, pp. 1119-1131. https://doi.org/10.1104/pp.114.241901

81. Sychuk, A.M., Radchenko, M.P. & Morderer, Ye.Yu. (2013). Programmed cell death in the pathogenesis induced by herbicides inhibitors of acetyl-CoA carboxylase. Biol. studiyi, 2, pp. 101-106 [in Ukrainian]. https://doi.org/10.30970/sbi.0702.294

82. Sychuk, A., Radchenko, M. & Morderer, Ye. (2013). The increase of phytotoxic action of graminicide fenoxaprop-P-ethyl by NO donor sodium nitroprusside. Science and education a new dimension: natural and technical science, 1 (2), No. 15, pp. 21-22.

83. Morderer, Ye.Yu., Palanytsa, M.P. & Rodzevich, O.P. (2008). Investigation of the participation of free radical oxidation reactions in the development of phytotoxic effects of graminicides. Fiziologia i biokhimia kult. rastenij, 40, No. 1, pp. 56-62 [in Ukrainian].

84. Palanytsa, M.P., Trach, V.V., Rodzevich, O.P. & Morderer, Ye.Yu. (2008). Possible participation of reactive oxygen species in the development of phytotoxic effects of graminicides. Fiziologia i biokhimia kult. rastenij, 40, No. 4, pp. 355-361 [in Ukrainian].

85. Palanytsa, M.P., Trach, V.V. & Morderer, Ye.Yu. (2009). The generation of reactive oxygen species under the action of graminicides and modificators of their phytotoxicity. Fiziologia i biokhimia kult. rastenij, 41, No. 4, pp. 328-334 [in Ukrainian].

86. Palanytsa, M.P., Sorokina, S.I. & Morderer, Ye.Yu. (2012). Reactive oxygen species and their transformation in the formation of rhizobia-legume symbiosis under the of herbicides action. Fiziologia i biokhimia kult. rastenij, 44, No. 4, pp. 302-311 [in Ukrainian].

87. Radchenko, M.P., Sychuk, A.M. & Morderer, Ye.Yu. (2013). The reducing of antagonism in the mixtures of herbicides through specific inhibitor of superoxide dismutase. Uch. zapysky Tavrich. nats. un-tu im. V.I. Vernads'koho. Ser. Biolohiya, khimiya, 26 (65), No. 3, pp. 161-168 [in Ukrainian].

88. Radchenko, M.P., Sychuk, A.M., Rodzevich, O.P. & Morderer, Ye.Yu. (2013). The increasing of graminicide fenoxaprop-P-ethyl selective phytotoxicity and state of prooxidant-antioxidant balance under the applying in tank mixture with synergistic and antagonistic herbicides. Fiziol. rast. genet., 45, No. 4, pp. 306-312 [in Ukrainian].

89. Radchenko, M.P., Sychuk, A.M. & Morderer, Ye.Yu. (2014). Decrease of the herbcide fenoxaprop phytotoxicity in the drought condition: the role of antioxidant enzymatic system. J. Plant Protection Res., 54, No. 4, pp. 390-394. https://doi.org/10.2478/jppr-2014-0058