Методом высокоэффективной жидкостной хроматографии анализировали надземную часть растений Tanacetum balsamita L. В результате выявлены 23 соединения фенольной природы, из которых идентифицированы 15, а именно флавоноиды лютеолин, апигенин, диосметин, акацетин, апигенин-7-биозид, акацетин-7-биозид, апигенин-7-гликозид, лютеолин-7-гликозид, диосметин-7-биозид, диосметин-7-гликозид, диосметин-7-рамнозид и гидроксикоричные кислоты n-кумаровая, кофейная, хлорогеновая, изохлорогеновая. Среди них доминировали изохлорогеновая кислота (35 % суммы выявленных фенольных соединений), диосметин-7-гликозид (4,76), диосметин-7-биозид (2,64), лютеонин (2,25), диосметин-7-рамнозид (2,17 %). Проведенный хроматографический анализ фенольных соединений надземной части Т. balsamita дает основание считать эти растения перспективным источником биологически активных соединений — флавоноидов и гидроксикоричных кислот.
Ключевые слова: Tanacetum balsamita L., Asteraceae, Zhytomir Polissya, introduction, fenolic compounds, flavonoids, hydroxycinnamic acids
Полный текст и дополнительные материалы
В свободном доступе: PDFЦитированная литература
1. Gulko, R.M. (2005). Dictionary of the World medicinal plants. Lviv: Liga-Pres [in Ukrainian].
2. Zaprometov, M.N. (1996). Phenolic compounds and their role in the life of plants: the 56th Timiryazev readings. Moscow: Nauka [in Russian].
3. Kukhareva, L.V., Tychina, I.N. & Savich, I.M. (1996, August). Pyrethrum balsamita (L.) Willd. in the conditions of Belarus. Proceedings of the II Intern. conf. Analysis and forecasting the results of introduction of ornamental and medicinal plants of the world flora in botanical gardens (pp.126), Minsk: Tehnalogia [in Russian].
4. Mashentseva, A.A. & Seytenbetov, T.S. (2010). Experimental and theoretical study of the relationship "structure-activity" of cinnamic acid derivatives. J. Siberian Federal University. Chemistry, No. 3, pp. 183-192 [in Russian].
5. Minarchenko, V.M. (2005). Medicinal vascular plants of Ukraine. Kyiv: Fitosociocentr [in Ukrainian].
6. Panchenko, S.V. (2011). Comparative characteristics of phenolic compounds from Valeriana stolonifera Czern and Valeriana grossheimic Worosch. Aktualni pitannya farmacevtichnoyi i medichnoyi nauki ta praktiki, 24, No. 1, pp.100-101[in Ukrainian].
7. Shaldayeva, T.M. (2009). Flavonoids of Artemisia dracunculus L. from natural habitats of Southern Siberia. Rastit. mir Aziatskoy Rossii, No. 1 (3), pp.105-110 [in Russian].
8. Alexieva, I., Mihaylova, D. & Popova, A. (2013). Evaluation of the antioxidant capacity of aqueous extracts of fresh Chrysanthemum balsamita L. leaves growing in Bulgaria. Scientific Works of the University of Ruse, 52, Ser. 10.2, pp. 88-91.
9. Bylaite, E., Venscutonis, R., Roozen, J.P. & Posthumus, M.A. (2000). Composition of essential oil of costmary [Balsamita major (L.) Desf.] at different growth phases. J. Agr. Food Chem., 48, No. 6, pp. 2409-2414. https://doi.org/10.1021/jf990245z
10. Gallori, S., Flamini, G., Billia, A.R., Morelli, I., Landini, A. & Vincieri, F.F. (2001). Chemical composition of some traditional herbal drug preparations: Essential oil and aromatic water of costmary (Balsamita suaveolens Pers.). J. Agr. Food Chem., 49, pp. 5907-5910. https://doi.org/10.1021/jf0107656
11. Hassanpouraghdam, M.B., Tabatabaie, S.J., Nazemyieh, H., Aflatuni, A. & Esnaashari, S. (2008). Chemical composition of the volatile oil from aerial parts of Tanacetum balsamita growing wild in northwest of Iran. Croatica Chem. Acta, 12, No. 3, pp. 26-35.
12. Hassanpouraghdam, M.B., Tabatabaie, S.J. & Nazemyieh, H. (2008). Chrysanthemum balsamita (L.) Baill.: a forgotten medicinal plant. Facta Univer. Series: Medicine and Biology, 15, No. 3. pp., 119-124.
13. Hassanpouraghdam, M.B., Tabatabaie, S.J., Nazemyieh, H. & Aflatuni, A. (2008). Effects of different concentrations of nutrient solution on vegetative growth and essential oil of costmary (Tanacetum balsamita). Agr. Sci., 18, No. 1, pp. 27-38.
14. Hassanpouraghdam, M. B., Tabatabaie, S. J., Nazemyieh, H. & Aflatuni, A. (2008). N and K nutrition levels affect growth and essential oil content of costmary (Tanacetum balsamita). J. Food Agr. Environ., 6, No. 2, pp. 150-154.
15. Hassanpouraghdam, M. B., Tabatabaie, S. J., Nazemyieh, H. & Vojodi, L. (2009). Volatile oil constrituents of alecost [Tanacetum balsamita L. ssp. balsamitoides (Schultz-Bip.)] growing wild in North-West of Iran. Herba polonica, 55, No. 1, pp. 53-59.
16. Ivancheva, S. & Tsvetkova, R. (2002). Comparative analysis of leaf exudates flavonoids in genus Tanacetum. Simposium on Flora of Southeastern Serbia and Neighbouring Regions. Dimitrovgrad (Yugoslavia), pp. 71-75.
17. Jaimand, K. & Rezaee, M. B. (2005). Chemical constituents of essential oils from Tanacetum balsamita L. ssp. balsamitoides (Schultz-Bip.) Grierson. from Iran. J. Essent. Oil Res., 17, pp. 565-566. https://doi.org/10.1080/10412905.2005.9698996
18. Kubo, A. & Kubo, I. (1995). Antimicrobial agents from Tanacetum balsamita. J. Natural Products, 58, No. 1, pp. 1565-1569. https://doi.org/10.1021/np50124a013
19. Marculescu, A., Hanganu, D. & Kinga, O.N. (2001). Qualitative and quantitative determination of the caffeic acid and chlorogenic acid from three chemovarieties of Chrysanthemum balsamita L. Roman. Biotech. Lett., 6, pp. 477-484.
20. Nakatani, N., Kayano, S., Kikuzaki, H., Sumino, K., Katagiri, K. & Mitani, T. (2000). Identification, quantitative determination and antioxidative activities of chlorogenic acid isomers in prune (Prunus domestica L.). J. Agr. Food Chem., 48, pp. 5512-5516. https://doi.org/10.1021/jf000422s
21. Nickavar, B., Amin, B.G. & Mehregan, B.N. (2003). Quercetine, a major flavonol aglycon from Tanacetum balsamita L. Iran. J. Pharm. Res., 2, pp. 249-250.
22. Perez-Alonco, M.J., Velasco-Negueruela, A. & Burzaco, A.T. (1992). Tanacetum balsamita L.: A medicinal plant from Guadalajara (Spain). Acta Hort., 306, pp. 188-193. https://doi.org/10.17660/ActaHortic.1992.306.19
23. Suresh, J., Fhuja, J., Paramakris Hnan, N. & Sebastian, M. (2012). Total phenolic and total flavonoids content of aerial parts of Artemisia abrotanum Linn. and A. pallens Wall. Analyt. Chem. Lett., 2, pp. 186-191. https://doi.org/10.1080/22297928.2000.10648268
24. Taguri, T., Tanaka, T. & Kouno, I. (2006). Antibacterial spectrum of plant polyphenols and extracts depending upon hydroxyphenyl group. Biol. Pharm. Bull., 29, pp. 2226-2235. https://doi.org/10.1248/bpb.29.2226
25. Williams, C.A., Harborn, J.B. & Eagles, J. (1999). Variations in lipophilic and polar flavonoids in the genus Tanacetum. Phytochemistry, 52, pp.1301-1306. https://doi.org/10.1016/S0031-9422(99)00425-2
26. Wollenweber, E., Dorr, M., Fritz, H. & Valant-Vetschera, K.M. (1997). Exudate flavonoids in several Asteroideae and Cichorioideae (Asteraceae). Z. Naturforsch., 52, pp. 137-143. https://doi.org/10.1515/znc-1997-3-401